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Conclusions Reduced-calorie diets result in clinically meaningful weight loss regardless of which macronutrients they emphasize. 312, No. (ClinicalTrials. Abstract Background The possible advantage for weight loss of a diet that emphasizes protein, fat, or carbohydrates has not been established, and there are few studies that extend beyond 1 year. Key differences between this analysis and recent joint guidelines from the American Heart Association (AHA), American College of Cardiology (ACC), and The Obesity Society (TOS) eFigure 1. GRADE confidence in indirect estimates: 12-month weight loss eTable 12. The diets improved lipid-related risk factors and fasting insulin levels. Difference in mean decrease in BMI at 6 and 12 months across diet classes with 95% credible intervals eTable 14. eMethods. Difference in mean weight loss at 6 and 12 months across all diet classes with 95% credible intervals when restricted to low risk of bias studies eTable 5. Difference in mean weight loss at 6 and 12 months across all diet classes with 95% credible intervals when adjusting for baseline weight (overweight to obese vs morbidly obese) eTable 7. Description of dietary programs eTable 2. The primary outcome was the change in body weight after 2 years in two-by-two factorial comparisons of low fat versus high fat and average protein versus high protein and in the comparison of highest and lowest carbohydrate content. JAMA 2014-09-02, Vol. Network diagrams for randomized controlled trials investigating weight loss among branded diets eFigure 4. GRADE overall confidence in estimates: 12-month weight loss eTable 13. Difference in mean weight loss at 6 and 12 months across all diet classes with 95% credible intervals when adjusting for proportion female (continuous measure) eTable 8.
eTable 1. gov number, NCT00072995. The diets consisted of similar foods and met guidelines for cardiovascular health. Difference in mean weight loss at 6 and 12 months across all diet classes with 95% credible intervals when adjusting for percentage loss to follow-up (continuous measure) eTable 6. The crucial question is whether overweight people have a better response in the long term to diets that emphasize a specific macronutrient composition. Thus, we recognized the need for a large trial that would be designed to overcome the limitations of previous trials and that would compare the effects of three principal dietary macronutrients. Participants Our goal was to recruit 800 overweight and obese subjects (400 at each site), of whom about 40% would be men. Supplement. Summary of risk of bias by diet class and brand eTable 3. Difference in mean weight loss at 6 and 12 months across all diet brands with 95% credible intervals when restricted to low risk of bias studies eTable 10. The project staff of the National Heart, Lung, and Blood Institute also participated in the development of the protocol, monitoring of progress, interpretation of results, and critical review of the manuscript. 9, Author Audio Interview. Network diagrams for randomized controlled trials investigating weight loss among diets, categorized by diet class eFigure 3. Difference in mean decrease in BMI at 6 and 12 months across diet brands with 95% credible intervals eTable 15. GRADE confidence in direct estimates: 12-month weight loss eTable 11. The participants were offered group and individual instructional sessions for 2 years. View Large Download Diet Classes Based on Macronutrient Composition Table 2. Media in This Article Poll Results Contributors Figure 1 Mean Change in Body Weight and Waist Circumference from Baseline to 2 Years According to Dietary Macronutrient Content. ) Full Text of Discussion. Figure 2 Mean Changes in Body Weight and Waist Circumference at Various Time Points.
